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GHB or Gamma Hydroxybutyrate (C4H8O3) is a central nervous system (CNS) depressant that is commonly referred to as a “club drug” or “date rape” drug. GHB is abused by teens and young adults at bars, parties, clubs and “raves” (all night dance parties), and is often placed in alcoholic beverages. Euphoria, increased sex drive, and tranquility are reported positive effects of GHB abuse.1,2 Negative effects may include sweating, loss of consciousness (reported by 69 percent of users), nausea, hallucinations, amnesia, and coma, among other adverse effects.

Xyrem (sodium oxybate), a brand name prescription drug was approved by the Food and Drug Administration (FDA) in 2002 for the treatment of narcolepsy, a sleep disorder that causes excessive sleepiness and recurring daytime sleep attacks. It is the sodium salt of gamma hydroxybutyrate. Xyrem is a highly regulated drug in the U.S. It is a Schedule III controlled substance, and requires patient enrollment in a restricted access program.

GHB is also a naturally-occurring metabolite of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) found in the brain. The naturally-occurring metabolite GHB is present in much lower concentrations in the brain than those levels found when the drug is abused. As a result of fermentation, natural GHB may also be found in small but insignificant quantities in some beers and wines.

High doses of GHB, even without other illicit substances or alcohol, may result in profound sedation, seizures, coma, severe respiratory depression and death. Emergency department episodes related to the use of club drugs usually involve the use of multiple substances, such as marijuana, cocaine, and other club drugs, such as methamphetamine, Ecstasy, or Rohypnol.
You will need :
1. 135 grams (120 ml)of gamma butyrolactone
2. 63 grams of Sodium Hydroxide or
91 grams of Potassium Hydroxide
3. Papers to test pH

1. Place the content of the gamma butyrolactone bottle in a stainless steel or pyrex glass saucepan. Do not use aluminum cookware to make GHB.
2. Place the content of the NaOH or KOH bottle in the same saucepan.
3. Put SLOWLY around a half cup of warm distilled water in it. Put a cover (fast! the reaction may be immediate) on it but not tight.
4. Wait a little it will start reacting on itself. If it doesn’t (after 2-3 minutes), heat it a LITTLE (once it reacts remove it from the stove).
4.5 If there is some NaOH not dissolved, stir it up till it is.
5. (This step is optional, some like it like that and others prefer to heat the solution a little.) After it’s finished. Start heating it slowly. You will see it starting boiling. Don’t overheat! It can burn. Do it for one hour. Don’t forget to add water if you make it boil for a long time.
5.5. Between step 4 and 6 you might see a white compound on the side of the saucepan (it doesn’t happen everytime). Don’t throw it away, it’s GHB. When you will add water, it will dissolve.
6. When you are finished, put it in a measuring cup (Pyrex) and fill it with water (when I’m in a hurry to taste it I use ice) to 1000ml (a little more than 4 cups). That way you’ll have around 1 grams per teaspoon.
7. Measure the PH. If it’s higher than 7.5 add vinegar to lower it to below 7.5 It can take 50 - 75 ml of vinegar.
9. To store it I use a mason glass jar with a plastic cover. I draw the poison logo on it (very important! you don’t want a kid to take a full glass of GHB). I place it in the fridge, the taste is better when it’s cold.

Another Way of making GHB:

You will need:

Clean dry beakers and graduated cylinders, a set of chemical scales, narrow range pH strips for 5.5-8.0, a hot plate, and (if you intend to make powder) two sealed tupperware containers, a blender and a pyrex baking dish.

1) Accurately measure out gamma-butyrolactone (GBL) in the volume of milliliters (mls) you want to react.
Example: You want to react 120 mls of GBL.
2) Multiply this number by the average density of GBL (1.124 gms/ml).
Example: (120 mls GBL) * (1.124 gms/ml) = 134.88 gms GBL
3) Divide this number by the average molecular weight of GBL (86.09 gms/mol).
Example: (134.88 gms GBL) / (86.09 gms/mol) = 1.567 mols of GBL
4) Multiply this number by the average molecular weight of NaOH (40.0 gms/mol)
Example: (1.567 mols) * (40.0) = 62.69 gms NaOH
5) Weigh out this much NaOH using a set of chemical scales.
6) Heat the GBL + 5% distilled water (by volume) to 100 degrees C
Example: 120 mls GBL + 6 mls distilled water heated to 100C
7) Completely dissolve the NaOH in distilled water at the rate of about 40 grams per 100 mls of water.
Example: (63 gms NaOH) / (40) = 1.575 * 100 mlw H2O = 157.5 mls water
8) *SLOWLY* drip (DO NOT POUR) 90% of the NaOH into the heated GBL and make sure that the reaction is occurring (the solution will begin boiling vigorously). If the reaction is not occuring, then you either have not heated the GBL to 100C or you have defective reactants (throw them out and get fresh stuff). Once the solution begins boiling, you can turn the heat off - the reaction will make its own heat.
9) Begin measuring the pH of the reaction solution with narrow range pH paper (5.0 - 8.0 paper). When the range begins to get to 7.5 to 8.0, stop dripping the NaOH solution. This mixture will still have unreacted lactone in it - so now it is time to do some steam distillation.
Steam Distillation (The purification step)
10) Put a thermometer in the solution capable of measuring 200C and crank the heat up on the solution. You may want to add a boiling stone made from a clean piece of pea gravel to the solution (don’t use a boiling stick because you will burn it up, and don’t use a chemical boiling stone because they contain metals that are not supposed to go into humans).
11) When the solution gets up to 150-155C, cut the heat back enough to hold the temperature steady at 150-155C. Hold it at that temperature until all bubbling stops. The beaker now contains melted NaGHB.
12a) To make a liquid, add enough boiling water to make the dilution you want.
Example: You want 1 gram NaGHB per 5 ml of solution. 120 mls of GBL will make 198 grams NaGHB. 198 * 5 ml = 990 mls of solution. So add enough boiling water to bring the entire solution up to 990 mls.
12b) To make powder, pour out thin strips of the NaGHB melt into the pyrex casserole dish. Return the melt to the low heat to keep it melted. Let the strips cool - they will begin to curl up if the strips are about 1/2″ to 1″ in width. Scrape them up with a metal spatula and put them into a sealed tupperware container. Pour out more strips and repeat the procedure until you have used up all of the melt.
13) Let the strips in the tupperware container cool down and shake them around a bit (while holding the lid tighly on). This will break up the strips.
14) Put the boken up NaGHB pieces into a blender (no more than 1/3 full) at high speed. You may have to shake the blender around a bit to make sure everything is ground into powder. Pour the powder into a sealed tupperware container.
15) You are done. Enjoy, and please don’t do G and drive.
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